Hepatitis C and hepatocellular carcinoma

Pathway model based on hub miRNAs and their putative targets from network analysis. * From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING (http://string-db.org/) and GeneMANIA (http://genemania.org/). * After topological analysis and network visualization in Cytoscape, the top hub genes were identified. * miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network. Based on Figure 4 from Poortahmasebi et al, How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3646 CPTAC Assay Portal]

基于网络分析，构建了以枢纽miRNA及其潜在靶点为基础的通路模型。通过对慢性丙型肝炎（HCV）和肝细胞癌（HCC）样本中差异表达基因集进行分析，运用STRING（http://string-db.org/）和GeneMANIA（http://genemania.org/）软件构建蛋白质-蛋白质网络。随后，在Cytoscape软件中对其进行拓扑分析和网络可视化，识别出关键枢纽基因。利用miRTarBase服务器识别与枢纽基因相关的miRNA，并将之与PPI网络结合，构建miRNA-枢纽基因网络。本描述基于Poortahmasebi等人在《基于网络的肝细胞癌研究：丙型肝炎病毒如何导致肝细胞癌》一文中第4图。该通路上的蛋白质可通过[https://assays.cancer.gov/available_assays?wp_id=WP3646 CPTAC检测门户]进行靶向检测。