The expression levels of mRNAs between miR-124-3p knockdown group and negative control group in mouse retina at postnatal day 9

Although the miR-124a-3p knockdown mouse exhibited neuronal dysfunction and dysmaturation by disinhibition of Lhx2, its downstream responses in mouse retinal development after birth were still relatively deficient at the transcriptome level. In our previous study, miR-124-3p exhibited a significantly increasing trend after birth, and its related pathways predicted by bioinformatics analysis were associated with biological processes that may play crucial roles in mouse retinal development. To gain insight into its downstream processes, RNA-Seq was used to obtain the expression profile of mRNA transcripts after the knockdown of miR-124-3p. Overall design: Retinal mRNA profiles of 6-day old miR-124-3p knockdown (anti-miR-124) and negative control (NC) mice