Supplementary Material for: Atypical presentation of COVID-19 in older adults: a scoping reviews

Background: COVID-19 has currently well-described signs and symptoms. However, older adults often present with an atypical condition, which can confuse and delay diagnosis and treatment. Summary: A scoping review was performed according to Joanna Briggs Institute methodology and prepared using the PRISMA-ScR. It included 61 studies. The objectives were to identify the atypical symptoms of COVID-19 in older adults and summarize and synthesize the evidence regarding the clinical outcomes of older adults with atypical presentations of COVID-19. Fifty-eight atypical symptoms were identified. Geriatric syndromes were the most prevalent atypical presentations of COVID-19. The prevalence of older adults with atypical presentation was 29 ± 18.45%. The mortality rate of older adults with atypical presentation was 28.3 ± 10.26 (17–37%). Key Messages: This scoping review showed that geriatric syndromes represent a frequent atypical presentation of COVID-19 in older adults. It is necessary to give visibility to those presentations in older populations with COVID-19 to advance the required interventions.

背景：目前新型冠状病毒肺炎（COVID-19）的典型体征与症状已有充分研究记载。但老年群体感染新冠后常表现为非典型病症，易引发临床诊断混淆，进而延误诊疗时机。
研究概况：本研究遵循乔安娜·布里格斯研究所（Joanna Briggs Institute）方法学开展，并采用PRISMA-ScR（系统综述与元分析首选报告规范-范围综述版）进行报告撰写。本次范围综述共纳入61项相关研究，旨在明确老年群体感染COVID-19的非典型症状，并总结、整合老年新冠患者以非典型表现发病时的临床结局相关证据。本综述共识别出58种非典型症状，其中老年综合征是新冠感染老年患者最常见的非典型临床表现。出现非典型表现的老年新冠患者占比为29%±18.45%，该类患者的死亡率为28.3±10.26（17%~37%）。
核心结论：本范围综述证实，老年综合征是老年群体感染COVID-19时常见的非典型临床表现。临床需重视新冠感染老年群体的此类非典型表现，以推动针对性干预措施的落地实施。