Sialic acid binds SIGLEC

Sialic acid binding immunoglobulins (Ig)-like lectins (SIGLECs) belong to I-type lectin with a selective expression on the haematopoetic cell lineages. These have amazing structural diversity each recognizing differently linked terminal sialic acid on glycoproteins and glycolipids expressed on host cells as well as pathogen (Powell & Varki 1995, Crocker 2002). Fifteen human SIGLECs have been identified so far. Interaction with various sialylated glycoconjugates, SIGLECs undertake various functions such as internalization of sialylated pathogens, attenuation of inflammation, restraining cellular activation, attenuation of damage-associated molecular pattern-mediated in?ammation along with inhibition of NK cell activation (von Gunten & Bochner 2008, Pillai et al. 2012, Matthew et al. 2014). The sialic acid-binding Ig-like lectins CD33 (SIGLEC3), SIGLEC7 and -9 are inhibitory receptors expressed on human NK cells and subsets of peripheral T cells that recognise sialic acid-containing carbohydrates (Hernández-Caselles et al. 2006, Falco et al. 1999).

唾液酸结合免疫球蛋白样凝集素（SIGLECs）属于I型凝集素，具有在造血细胞谱系中选择性表达的特点。这些凝集素展现出惊人的结构多样性，每一类均能识别宿主细胞及病原体表面表达的糖蛋白和糖脂上不同连接的唾液酸末梢（Powell & Varki 1995，Crocker 2002）。迄今为止，已鉴定出十五种人类SIGLECs。SIGLECs通过与各种唾液酰化糖基化合物的相互作用，执行多种功能，如唾液酰化病原体的内化、炎症的减轻、细胞活化的抑制、损害相关分子模式介导的炎症的减轻，以及自然杀伤细胞活化的抑制（von Gunten & Bochner 2008，Pillai et al. 2012，Matthew et al. 2014）。唾液酸结合的Ig样凝集素CD33（SIGLEC3）、SIGLEC7和SIGLEC9是表达在人类自然杀伤细胞和某些外周T细胞上的抑制性受体，它们能够识别含有唾液酸糖基的碳水化合物（Hernández-Caselles et al. 2006，Falco et al. 1999）。