Total Synthesis of an Oxepine Natural Product, (±)-Janoxepin
收藏Figshare2016-02-22 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Total_Synthesis_of_an_Oxepine_Natural_Product_Janoxepin/2549506
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资源简介：
The total synthesis of (±)-janoxepin, a novel antiplasmodial d-leucine derived oxepine-pyrimidinone-ketopiperazine isolated from the fungus Aspergillus janus, is described. The cornerstones of the synthetic route are pyrimidinone preparation, ring-closing metathesis, aldol introduction of the enamide, and dihydro-oxepine elaboration. This synthetic route proved very efficient for the formation of a number of janoxepin analogues, including dihydro-janoxepin and tetrahydro-janoxepin.
创建时间：
2016-02-22
