Highly Enantioselective Hydrogenation of Steric Hindrance Enones Catalyzed by Ru Complexes with Chiral Diamine and Achiral Phosphane

An asymmetric hydrogenation of sterically
hindered β,β-disubstituted
enones has been well-established by using a ruthenium complex composed
of an achiral diphosphane and a chiral diamine as catalyst, wherein
the carbonyl group was selectively hydrogenated to give a wide range
of chiral allylic alcohols with high levels of enantio­selectivity
and complete chemo­selectivity.