Cadmium exposure induces changes in intestinal microbial structure and metabolic function in long-tailed hamsters (Cricetulus longicaudatus)

Many studies have shown that exposure to heavy metals can disrupt the diversity and composition of the gut microbiota, resulting in a significant decrease in gut microbial richness but the broader ecological reality is lacking. In this study, we comprehensively evaluated the effects of exposure to 6 mg/L、12 mg/L、24 mg/L and 48 mg/L Cd in drinking water for 35 days on the intestinal microbiota of long-tailed hamsters, Cricetulus longicaudatus (Rodentia: Cricetidae). The results suggest that Cd exposure induces changes in intestinal morphology in Cricetulus longicaudatus that may increase intestinal permeability and inflammation, but their body weight instead increases. These changes were accompanied by significant perturbations of the gut microbiota, resulting in significant alterations in microbial abundance. Additionally, Cd exposure induced significant changes in the metabolic functions of the gut microbiota, with over half of the metabolic functions in the Cd-treated g..., , , # Cadmium exposure induces changes in intestinal microbial structure and metabolic function in long-tailed hamsters (Cricetulus longicaudatus)

[https://doi.org/10.5061/dryad.zgmsbcckt](https://doi.org/10.5061/dryad.zgmsbcckt)

In this study, we conducted a 35d Cd exposure test on *C. longicaudatus*. HE staining, 16S rDNA sequencing and metagenomic sequencing were used to investigate organ tissue damage, gut microbial diversity and composition disorders. Based on metagenomics, the study also examined changes in metabolic function and gut microbial function of *C. longicaudatus*. The results of this study are helpful for us to understand the response of wild rodents to Cd pollution and the series of changes that occur in their gut microbiota and physiological ecology.

## Description of the data and file structure

The dataset comprises 16S rDNA sequencing and metagenomic sequencing. The uploaded 16S data specifically refers to the 16S rDNA sequencing results. Within the compressed folde...

已有多项研究表明，重金属暴露会破坏肠道微生物群（gut microbiota）的多样性与组成，导致肠道微生物丰富度显著下降，但目前尚缺乏该现象背后更广泛的生态学现实证据。本研究全面评估了为期35天的饮用水中镉（Cadmium, Cd）暴露（浓度分别为6 mg/L、12 mg/L、24 mg/L与48 mg/L）对长尾仓鼠（Cricetulus longicaudatus，啮齿目：仓鼠科）肠道微生物群的影响。研究结果显示，镉暴露会引发长尾仓鼠的肠道形态改变，这可能会增加肠道通透性与炎症反应，但受试个体的体重反而出现上升。上述变化伴随肠道微生物群发生显著扰动，进而导致微生物丰度出现明显改变。此外，镉暴露会引发肠道微生物群代谢功能的显著变化，镉处理组中超过半数的代谢功能……
# 镉暴露可改变长尾仓鼠（Cricetulus longicaudatus）的肠道微生物结构与代谢功能

[https://doi.org/10.5061/dryad.zgmsbcckt](https://doi.org/10.5061/dryad.zgmsbcckt)

本研究针对长尾仓鼠（*C. longicaudatus*）开展了为期35天的镉暴露实验。通过苏木精-伊红（HE）染色法、16S rDNA测序（16S rDNA sequencing）以及宏基因组测序（metagenomic sequencing），本研究分别探究了受试个体的器官组织损伤、肠道微生物群多样性与组成紊乱情况。基于宏基因组学分析，本研究同时考察了长尾仓鼠的代谢功能与肠道微生物功能变化。本研究结果有助于我们理解野生啮齿类动物对镉污染的响应，以及其肠道微生物群与生理生态所发生的一系列变化。

## 数据集与文件结构说明

本数据集包含16S rDNA测序与宏基因组测序数据。上传的16S数据特指16S rDNA测序结果。在压缩文件夹中……