Validity and reliability of the Brazilian Portuguese version of the Australian National University - Alzheimer’s Disease Risk Index (ANU-ADRI)

Abstract The ANU-ADRI is a self-report tool that assesses risk for Alzheimer’s Disease (AD). Objective: To validate an adapted Portuguese version of this instrument and to carry out the reliability Test-Retest of the ANU-ADRI in Brazil. Methods: In this longitudinal study, the sample was formed (n=100) by two groups (A and B): each comprising 50 patients assisted by GPs (general practitioners) or specialists in dementia. All participants were cognitively healthy upon screening using the MMSE. The ANU-ADRI was applied at baseline (Test) and again within 1 week of the test (Retest). Results: There was a correlation between the mean scores of the ANU-ADRI Test and Retest (r=0.918, P<0.001). Group A had higher ANU-ADRI scores than those of group B (P<0.05). There was a moderate negative linear relation between the ANU-ADRI and MMSE scores (r= -0.353, P<0.001). Conclusion: The ANU-ADRI is a valid and reliable instrument to assess whether community-dwelling Brazilians are at greater risk for AD. Low levels of education were associated with higher risk scores on the ANU-ADRI.

摘要：ANU-ADRI是一款用于评估阿尔茨海默病（Alzheimer’s Disease, AD）患病风险的自评工具。
研究目的：验证该工具经适配后的葡萄牙语版本，并在巴西开展ANU-ADRI的重测信度检验。
研究方法：本项纵向研究共纳入100名受试者，分为A、B两组，每组各50名，受试者均由全科医生或痴呆专科医师提供诊疗服务。所有受试者经简易精神状态检查表（Mini-Mental State Examination, MMSE）筛查后被评定为认知健康状态。研究分别在基线阶段（首次测试）以及首次测试后1周内（重测）两次施测ANU-ADRI量表。
研究结果：ANU-ADRI首次测试与重测的平均得分呈显著正相关（r=0.918, P<0.001）。A组的ANU-ADRI平均得分显著高于B组（P<0.05）。ANU-ADRI得分与MMSE得分呈中度负线性相关（r=-0.353, P<0.001）。
研究结论：ANU-ADRI是一款可有效评估巴西社区居民阿尔茨海默病患病风险的可靠且有效的工具。低教育水平与ANU-ADRI较高的风险得分呈显著关联。