Nanoparticle Uptake in a Spontaneous and Immunocompetent Woodchuck Liver Cancer Model

We characterized the identity of hepatic macrophages from the uninvolved liver of a WHV-positive (area with no visible tumor) tumor bearing woodchuck that take up NPs using RNA-sequencing (RNA-seq). Data from WHV-infected animal from experiment 3. We performed fluorescence activated cell sorting (FACS) analysis on dissociated, live cells from the uninvolved liver (area with no visible tumor) of a WHV-positive tumor bearing woodchuck and sorted into 4 groups: CD14+NP-, CD14-NP-, CD14-NP+, and CD14+NP+. We profiled the molecular signatures of these four cell populations using RNA-seq