c-Met activation leads to the establishment of a TGFb regulatory network required for bladder cancer invasion

Aberrant c-Met activation and upregulation of its cognate ligand HGF are frequently observed in bladder cancer and have been shown to regulate downstream pathways involved in proliferation, motility, and invasion. The precise mechanism underlying HGF/c-MET mediated invasion in bladder cancer is partly addressed by this microarray dataset. HGF activates the canonical TGFb signaling pathway to enhance epithelial mesenchymal transition and bladder carcinoma invasion. NBTII cell line were treated with HGF at timepoint 0 hr, 2 hr, 4 hr, 6 hr, 9 hr, 24 hr and 48 hr.