Causal study of osteoporosis and abdominal aortic calcification (ACC): a Mendelian randomization study

An association between osteoporosis and abdominal aortic calcification (ACC) has been consistently observed in various clinical studies. However, the underlying genetic relationship between these two conditions remains uncertain. Despite the extensive research conducted on the topic, there is a lack of conclusive evidence regarding the existence of a genetic link between osteoporosis and ACC. Further investigations are warranted to elucidate the potential genetic factors -contributing to this association and to enhance our understanding of the pathophysiological mechanisms involved.

已有多项临床研究反复证实，骨质疏松症（osteoporosis）与腹主动脉钙化（abdominal aortic calcification, ACC）之间存在关联。然而，二者之间潜在的遗传关联仍未明确。尽管针对该主题已开展了大量研究，但目前仍缺乏确凿证据证明二者存在遗传关联。亟需开展进一步研究，以阐明介导该关联的潜在遗传因素，并加深我们对其所涉及的病理生理机制的理解。