Scn10a

Enables voltage-gated sodium channel activity. Involved in behavioral response to pain; circadian rhythm; and detection of stimulus involved in sensory perception. Acts upstream of or within several processes, including cardiac conduction; regulation of atrial cardiac muscle cell membrane depolarization; and sodium ion transport. Located in C-fiber and plasma membrane. Is expressed in brain; ganglia; and heart. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 2. Orthologous to human SCN10A (sodium voltage-gated channel alpha subunit 10). [provided by Alliance of Genome Resources, Nov 2024]

该基因调控电压门控钠通道活性，参与痛觉行为反应、昼夜节律以及与感官感知相关的刺激检测。该基因在心脏传导、心房心肌细胞膜去极化调节及钠离子转运等过程中发挥上游或内部作用。基因定位在C纤维和质膜上，表达于大脑、神经节和心脏。该基因的人源同源物与家族性发作性痛症2相关。与人源SCN10A（钠电压门控通道α亚基10）同源。[由基因组资源联盟提供，2024年11月]