Structure of Hs/AcPRC2 in complex with a pyridone inhibitor
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Structure of Hs/AcPRC2 in complex with a pyridone inhibitor Descriptor: 5,8-dichloro-2-[(4-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-({1-[(2R)-2-hydroxypropanoyl]piperidin-4-yl}oxy)-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... Authors: Gajiwala, K.S, Brooun, A, Deng, Y.-L, Liu, W. Deposit date: 2016-03-01 Release date: 2016-05-04 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance. Nat Commun, 7, 2016
创建时间：
2016-03-01
