Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicity

Abstract Amphotericin B is a fungicidal substance that is treatment of choice for most systemic fungal infections affecting immunocompromised patients. However, severe side effects have limited the utility of this drug. The aim of this study was to evaluate the antifungal effect of the combination of amphotericin B with black tea or white tea and protective of citotoxic effect. The present study shows that white and black teas have additive effects with amphotericin B against some species Candida. In addition, the combination of white and black tea with amphotericin B may reduce the toxicity of amphotericin B to red blood cells. Our results suggest that white and black tea is a potential agent to combine with amphotericin for antifungal efficacy and to reduce the amphotericin dose to lessen side effects.

摘要 两性霉素B（Amphotericin B）是一类杀真菌物质，为多数累及免疫受损患者的系统性真菌感染的首选治疗药物。然而，其严重的不良反应限制了该药物的临床应用价值。本研究旨在评估两性霉素B分别与红茶、白茶联合使用时的抗真菌效果，以及其对细胞毒性的保护作用。本研究结果显示，白茶与红茶可与两性霉素B产生相加效应，对部分念珠菌（Candida）属菌株具有抗真菌活性。此外，白茶、红茶与两性霉素B联合给药可降低两性霉素B对红细胞的毒性。本研究结果表明，白茶与红茶可作为潜在的联合用药辅助剂，与两性霉素B联用以提升抗真菌疗效，并通过降低两性霉素B的给药剂量来减轻其不良反应。