Table S1 - Consequences of Daily Administered Parathyroid Hormone on Myeloma Growth, Bone Disease, and Molecular Profiling of Whole Myelomatous Bone

Genes whose expression was significantly upregulated or downregulated by PTH treatment in whole human bone from SCID-hu mice. SCID-hu mice engrafted with Hg myeloma cells were treated with saline or PTH for 4 weeks. Mice were sacrificed 2 hours after the last injection. RNA extracted from the whole myelomatous human bone (five bones/group) was subjected to global gene expression profiling. Positive (POS) or negative (NEG) expression of those genes in Hg myeloma cells is indicated to assess cellular source of these genes (e.g., microenvironmental and/or tumor cells).
(XLS)