Huntingtin Interaction Network

This repository is no longer available. The main objective of our work is to understand the pathomechanisms of late onset neurodegenerative disorders such as Huntington's, Parkinson's, Alzheimer's and Machado Joseph disease and to develop causal therapies for them. The disease causing proteins of these illnesses have been identified, but their functions in the unaffected organism are mostly unknown. Here, we have developed a strategy combining library and matrix yeast two-hybrid screens to generate a highly connected PPI network for Huntington's disease (HD).

本仓库已不再可用。本研究的主要目标是揭示诸如亨廷顿病、帕金森病、阿尔茨海默病以及马查多-约瑟夫病等迟发性神经退行性疾病的病理机制，并针对这些疾病开发因果治疗方法。这些疾病的致病蛋白已被识别，然而其在未受影响生物体中的功能大多尚属未知。在本研究中，我们已开发出一种策略，该策略结合了文库和矩阵酵母双杂交筛选，旨在为亨廷顿病（HD）构建一个高度连接的蛋白质相互作用网络（PPI）。