PPARG
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=69168
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资源简介：
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
本基因编码的是过氧化物酶体增殖激活受体（PPAR）亚家族的核受体之一。PPARs与视黄酸X受体（RXRs）形成异源二聚体，这些异源二聚体调节多种基因的转录。已知PPARs有三种亚型：PPAR-α、PPAR-δ和PPAR-γ。由本基因编码的蛋白质为PPAR-γ，它是一种调控脂肪细胞分化的调节因子。此外，PPAR-γ还与多种疾病的病理机制有关，包括肥胖、糖尿病、动脉粥样硬化和癌症。已描述了不同剪接转录本变异体，它们编码不同的异构体。[由RefSeq提供，2008年7月]
提供机构：
Rat Genome Database
