Immunosuppressive effect of rfNSCs-IDO in EAE animal model.

Immunization with MOG and CFA induced acute inflammation in 6 week-old female SD rats. (A) EAE-induced rats exhibited swollen feet with hind limb paralysis. (B) The intravenous injection of rfNSCs-Cont, rfNSCs-IDO, or HBSS was performed through the rat tail vein at 5 dpi after EAE induction. The total EAE experiment took 37 days. (C) The rfNSCs-IDO group maintained similar body weight to non-EAE control group, whereas the HBSS group showed weight loss throughout the experimental period. (D) According to EAE clinical scoring chart, it was observed that the recovery rate of rfNSCs-IDO group was significantly faster than that of HBSS control group (n = 7 for each group, * p < 0.05, ** p < 0.01).