Association between psoriasis and risk of dementia: a systematic review and meta-analysis - Supplemental Material

Supplemental File for Research Letter on the association between psoriasis and risk of dementia published in the Journal of the American Academy of Dermatology. Psoriatic inflammation and associated vascular disease could predispose patients to dementia. Several observational studies have examined the association between psoriasis and dementia, with conflicting findings. The aim of this systematic review is to examine the prevalence or incidence of dementia in adults with psoriasis, compared to adults without psoriasis in a systematic review and meta-analysis of observational studies. We searched MEDLINE and Embase databases up to January 2020 with no lower limit on year of publication. We performed title and abstract, full text screening, and data extraction in pairs. We used random effects meta-analysis to calculate pooled hazard ratios and 95% confidence intervals for the association between psoriasis and dementia. Our search yielded 928 studies of which we included 8 for narrative synthesis and 4 in meta-analysis. Psoriasis was non-significantly associated with dementia overall (HR 1.18, 95% CI, 0.93-1.50), with a stronger association seen with vascular dementia (HR 1.43, 95% CI, 1.35-1.53) than dementia of the Alzheimer type (HR 1.08, 95% CI, 1.01-1.16). Psoriasis may be associated with an increased risk for vascular dementia, more than other forms of dementia.

发表于《美国皮肤病学会杂志》（Journal of the American Academy of Dermatology）的关于银屑病（psoriasis）与痴呆（dementia）风险相关性研究快报的补充材料。银屑病性炎症及伴随的血管病变可能使患者易罹患痴呆。已有多项观察性研究探讨了银屑病与痴呆的相关性，但所得结论并不一致。本系统综述与荟萃分析旨在针对观察性研究，对比银屑病成人患者与非银屑病成人群体的痴呆患病率或发病率。我们检索了MEDLINE与Embase数据库，检索时限截至2020年1月，未设置文献发表年份下限。我们采用双人配对法完成标题与摘要、全文筛查及数据提取工作。我们采用随机效应模型进行荟萃分析，以计算银屑病与痴呆相关性的合并风险比（HR）及95%置信区间（CI）。本次检索共获928项研究，最终纳入8项用于叙述性综合分析，4项用于荟萃分析。总体而言，银屑病与痴呆无显著相关性（HR=1.18，95%CI=0.93~1.50）；其中与血管性痴呆的相关性更强（HR=1.43，95%CI=1.35~1.53），而与阿尔茨海默病型痴呆的相关性较弱（HR=1.08，95%CI=1.01~1.16）。银屑病或与血管性痴呆风险升高相关，且该相关性较其他类型痴呆更为显著。