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RNA-seq on mouse E11.5 ventral midbrain neurosphere cultures treated with the LXR agonist GW3965 and the GSK3beta inhibitor CT99021

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE66160
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We investigated mechanisms by which LXRs regulate midbrain dopaminergic neuron development. Using a systems biology approach, we found that LXR interacts with β-catenin and that LXR activation inhibits the activity of the Wnt/β-catenin pathway Three replicates each of control, GW3965-treated, CT990212 treated, and combined GW3965+CT99021 treated
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2020-05-05
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