Prevalence of sleep-disordered breathing after stroke and TIA: a meta-analysis

Objective: To perform a systematic review and meta-analysis on the prevalence of sleep-disordered breathing (SDB) after stroke. Methods: We searched PubMed, Embase (Ovid), the Cochrane Library, and CINAHL (from their commencements to 7th of April 2017) for clinical studies reporting prevalence and/or severity of SDB after stroke or transitory ischemic attack (TIA). Only sleep apnea tests performed with full polysomnography and diagnostic devices of the AASM categories I-IV were included. We conducted random-effects meta-analysis. PROSPERO registration number: CRD42017072339. Results: The initial search identified 5211 publications. 89 studies (including 7096 patients) met inclusion criteria. 54 studies were performed in the acute phase after stroke (after less than 1 month), 23 studies in the subacute phase (after 1-3 months) and 12 studies in the chronic phase (after more than 3 months). Mean apnea-hypopnea index (AHI) was 26.0/h (SD 21.7-31.2). Prevalence of SDB with AHI greater than ...

研究目标：针对卒中后睡眠呼吸障碍（sleep-disordered breathing, SDB）的患病率开展系统评价与荟萃分析。
研究方法：本研究检索了PubMed、Embase（Ovid平台）、Cochrane图书馆及CINAHL数据库（建库起始至2017年4月7日），旨在获取报告卒中或短暂性脑缺血发作（transitory ischemic attack, TIA）后睡眠呼吸障碍患病率和/或严重程度的临床研究。仅纳入采用全整夜多导睡眠监测及美国睡眠医学学会（American Academy of Sleep Medicine, AASM）I-IV类诊断设备完成的睡眠呼吸暂停检测相关研究。本研究采用随机效应模型开展荟萃分析。本研究已于PROSPERO国际前瞻性系统评价注册平台注册，注册号为CRD42017072339。
研究结果：初步检索共检出5211篇文献，最终89项研究（合计纳入7096名患者）符合纳入标准。其中54项研究针对卒中后急性期（发病不足1个月），23项针对亚急性期（发病1~3个月），12项针对慢性期（发病超过3个月）。受试者的平均呼吸暂停低通气指数（apnea-hypopnea index, AHI）为26.0次/小时（标准差范围21.7~31.2次/小时）。呼吸暂停低通气指数大于……的睡眠呼吸障碍患病率为……