Determining anthelmintic residues in goat milk in Brazil

SUMMARY Anthelmintics are used to combat nematodes. The misuse of anthelmintics can raise the cost of milk production. The objective of this research was to determine the presence of anthelmintics in goat milk. Twenty goats were used, divided into four groups of five animals: I- animals treated with an ivermectin-based anthelmintic; II- animals treated with moxidectin; III- animals treated with levamisole hydrochloride; and IV: animals treated with albendazole. Milk samples were collected individually: before, and 1, 2, 3, 15 and 21 days after administration of the anthelmintics. Determination of anthelmintic residues was performed by liquid chromatography-mass spectrometry (LC-MS). According to the results, there was an exponential effect (P<0.05) for ivermectin and moxidectin. Moxidectin was the anthelmintic that left a residue in the milk for the longest time, up to 21 days. However, with all the anthelmintics researched, residues were below the maximum limit recommended by the inspecting agencies.

摘要：抗蠕虫药（anthelmintics）主要用于防治线虫感染。抗蠕虫药的滥用会提升牛奶生产的成本。本研究旨在检测山羊乳中抗蠕虫药的残留情况。实验选取20只山羊，分为4组，每组5只：I组为接受伊维菌素类抗蠕虫药治疗的受试山羊；II组为接受莫西菌素治疗的受试山羊；III组为接受盐酸左旋咪唑治疗的受试山羊；IV组为接受阿苯达唑治疗的受试山羊。分别于给药前及给药后1、2、3、15、21天采集个体乳样。采用液相色谱-质谱联用法（liquid chromatography-mass spectrometry，LC-MS）对抗蠕虫药残留进行检测。结果显示，伊维菌素与莫西菌素的残留水平呈现指数级变化趋势（P<0.05）。其中莫西菌素是本次研究中残留持续时间最长的抗蠕虫药，其残留可在乳中留存至21天。不过所有受试抗蠕虫药的残留量均低于监管机构推荐的最大残留限量。