Data from: The global antigenic diversity of swine influenza A viruses

Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans.

猪流感（Swine influenza）给全球猪群带来了沉重的疾病负担，同时对人类构成潜在的大流行威胁。由于频繁有来自人类和禽类的病毒传入，加之全球猪群存在地理隔离，猪群中循环的H1和H3亚型流感病毒均存在相当程度的多样性。这类多样性大多已通过遗传学手段得到表征，但这些病毒的抗原多样性却鲜为人知。至关重要的是，抗原多样性会从兽疫流行和大流行潜力的角度，塑造猪流感病毒的风险特征。本研究依托迄今汇编的最全面的猪流感病毒抗原数据集，在多大陆尺度上量化了猪流感病毒的抗原多样性。全球不同地区近期流行病毒所具备的显著抗原多样性，为猪只流动的风险评估以及猪源人类感染的潜在可能性增添了复杂性。