Verification of monocyte trafficking behavior.

Simulations of adhesion molecule knockouts produced reductions in monocyte extravasation, which were in agreement with independent studies. The average rolling distances of monocytes were comparable to values reported in the literature for rolling monocytes in vivo. In some cases, independently reported literature values include data derived from other leukocyte subpopulations, in vitro data, inhibition studies (not knockout), and/or skeletal muscle exercise model. A 0% reduction may also denote non-significant changes in extravasation or firm adhesion, and/or significant increases in extravasation.