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The dynamic interactome and genomic targets of Polycomb complexes during stem cell differentiation

ChEBI2016-05-17 更新2026-07-12 收录

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干细胞分化

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-74330 数据链接链接失效反馈

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The dynamic interactome and genomic targets of Polycomb complexes during stem cell differentiation

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2016-05-17

朊病毒与细胞衰老

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Organisms often commit to one of two strategies: living fast and dying young or living slow and dying old. In fluctuating environments, however, switching between these two strategies could be advanta

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Addressing the specific roles of histone modifications in transcriptional repression [RNA-seq]

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Our understanding of epigenetic processes is based on the hypothesis that individual posttranslational modifications of DNA and histones, or combinations thereof, function to direct unique downstream

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Mitochondrial Fission 1 (FIS1) knockdown effect on the H3K27Ac status of leukemia cell line MOLM-13 cells. Mitochondrial Fission 1 (FIS1) knockdown effect on the H3K27Ac status of leukemia cell line MOLM-13 cells

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肾病与白血病基因功能研究

To examine if loss of FIS1 would alter the H3K27Ac status of leukemic cells, we used shRNA to knock down the expression of FIS1 in leukemic cell line MOLM-13 cells and performed H3K27Ac CHIP-seq to ch

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DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation [RNA-seq]

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DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

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An epigenetic switch in vascular phenotype augments anti-tumor immunity [bulkRNA-seq]

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The abnormal tumor vasculature can present a barrier to the infiltration of anti-tumor immune cells, which impairs immune surveillance and response to immunotherapy. Here, we show that targeting the e

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The dynamic interactome and genomic targets of Polycomb complexes during stem cell differentiation

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