Distribution of calbindin-positive neurons across areas and layers of the marmoset cerebral cortex (v1)

The dataset includes three-dimensional, whole-brain density maps of neurons that express the calcium-binding protein Calbindin (CB+) from three Common marmoset (Callithrix jacchus) monkeys. It also contains microscopic resolution images (×20 magnification, 0.5 µm/px) of individual immunostained sections.
The quantitative estimates of the CB+ densities are provided for 116 cortical areas currently recognized in the marmoset cerebral cortex, divided into supragranular, granular, and infragranular layers across each of the three individuals. The identification of the CB+ neurons was performed automatically using a tailored convolutional neural network trained on the examined dataset. For each brain, the density maps, along with the segmentation into areas and layers, are available as NIfTI files, while the high-resolution microscopic images are provided in TIFF format. Lastly, the dataset offers tabulated results in the form of an XLSX spreadsheet.
The dataset is released under the CC-BY license, and researchers are encouraged to use the NIfTI files for any spatially oriented analyses. The high-resolution images may be used for detailed studies of CB+ density patterns at a microscopic level, reproducing mesoscopic-resolution density maps, for educational purposes, and for developing automated cell segmentation improvement methods. The tabulated results are especially beneficial for cross-species analyses of the CB+ density patterns.