FAIRsharing record for: Reactome

This FAIRsharing record describes: The cornerstone of Reactome is a freely available, open source relational database of signaling and metabolic molecules and their relations organized into biological pathways and processes. The core unit of the Reactome data model is the reaction. Entities (nucleic acids, proteins, complexes, vaccines, anti-cancer therapeutics and small molecules) participating in reactions form a network of biological interactions and are grouped into pathways. Examples of biological pathways in Reactome include classical intermediary metabolism, signaling, transcriptional regulation, apoptosis and disease. Inferred orthologous reactions are available for 15 non-human species including mouse, rat, chicken, zebrafish, worm, fly, and yeast.

本FAIRsharing记录描述的内容如下：Reactome数据库的核心基石为一套可免费获取的开源关系型数据库，收录信号传导与代谢分子及其相互关联，并将这些内容整理为生物学通路与过程。Reactome数据模型的核心单元为生物反应。参与此类生物反应的实体（包括核酸、蛋白质、复合物、疫苗、抗癌治疗药物以及小分子）构成了生物相互作用网络，并被归类至各个通路中。Reactome数据库收录的生物学通路示例包括经典中间代谢、信号传导、转录调控、细胞凋亡以及疾病相关通路。该数据库还为15种非人类物种提供了推断得到的同源生物反应，涵盖小鼠、大鼠、鸡、斑马鱼、秀丽隐杆线虫、果蝇以及酵母。