Human Protein Atlas - Brain

This resource provides comprehensive spatial profiling of the Brain, including overview of protein expression in the mammalian brain based on integration of data from human, pig and mouse. Transcriptomics data combined with affinity-based protein in situ localization down to single cell detail is available in this brain-centric sub atlas of the Human Protein Atlas. The data presented are for human genes and their one-to-one orthologues in pig and mouse. Gene summary pages provide the hierarchical expression landscape form 13 main regions of the brain to individual nuclei and subfields for every protein coding gene. For selected proteins, high content images are available to explore the cellular and subcellular protein distribution. In addition, the Brain resource contains lists of genes with elevated expression in one or a group of regions to help the user identify unique protein expression profiles linked to physiology and function.
More information about the specific content and the generation and analysis of the data in this resource can be found on the Methods Summary.
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Expression levels for all human proteins in regions and subregions of the human brain
Expression levels for all proteins with human orthologs in regions and subregions of the pig and mouse brain
Brain enriched genes with higher expression in any of the regions of the brain compared to peripheral organs
Regional enriched genes with higher expression in a single or few regions of the brain
Cell-type and cell-compartment distribution of selected proteins in the human and mouse brain
Differences in gene expression between mammalian species

Additional information:
In addition to the data provided in the brain resource there is also data on human retina and single cell data containing information on protein expression in human neuronal and non-neuronal cell-types in the central nervous system.

本资源全面描绘了大脑的空间特征，包括基于整合人类、猪和老鼠数据的大脑蛋白质表达概述。本大脑中心子图谱提供了转录组数据与基于亲和力的蛋白质原位定位数据，直至单细胞水平。所展示的数据涉及人类基因及其在猪和老鼠中的单一位点直系同源基因。基因摘要页面展示了从大脑13个主要区域到每个蛋白质编码基因的单独核和亚区域的层级表达景观。对于部分选定的蛋白质，提供了高内涵图像以探索细胞和亚细胞蛋白质分布。此外，大脑资源还包括了在特定区域或一组区域中表达升高的基因列表，以帮助用户识别与生理和功能相关的独特蛋白质表达谱。更多关于资源具体内容、数据生成和分析方法的信息，可在方法摘要中找到。了解以下内容：
- 人类大脑各个区域和亚区域中所有人类蛋白质的表达水平
- 在猪和老鼠大脑的各个区域和亚区域中，所有与人类直系同源蛋白质的表达水平
- 在大脑区域中表达水平高于外周器官的富集基因
- 在大脑单个或少数区域中表达水平较高的区域富集基因
- 人类和老鼠大脑中选定蛋白质的细胞类型和细胞器分布
- 哺乳动物物种之间基因表达的差异
此外，大脑资源中还包括人类视网膜数据以及包含中枢神经系统人类神经元和非神经元细胞类型蛋白质表达信息的单细胞数据。