Clear cell carcinoma of the ovary and venous thromboembolism: a systematic review and meta-analysis

As the second most common subtype of Epithelial ovarian cancers (EOCs), ovarian clear cell carcinoma (OCCC) is associated with a high rate of cancer-associated thrombosis. Previous studies revealed the wide range prevalence (6–42%) of venous thromboembolism (VTE) among OCCC patients. This study aimed to determine the prevalence of VTE among OCCC patients as well as factors affecting it. PubMed, Scopus, Embase, and Cochrane Library databases were searched up to December 12^th, 2022. Studies reporting venous thromboembolic events in women with clear cell carcinoma of the ovary were included. Demographic data, clinical, and paraclinical features of the patients were independently extracted by two reviewers. Out of the 2254 records, 43 studies were processed for final review. The qualified studies involved 573 VTE cases among 2965 patients with OCCC. The pooled prevalence of VTE among OCCC patients was 21.32% (95%CI=(17.38–25.87)). Most VTE events were reported in Japanese women (26.15%), followed by Americans (24.41%) and UK (21.57%), and Chinese (13.61%) women. VTE was more common in patients with advanced stages (37.79%) compared to those with early stages of the disease (16.54%). Ovarian clear cell carcinoma is associated with a high rate of cancer-associated thrombosis. VTE events in OCCC patients were higher in advanced stages and Japanese women.

作为上皮性卵巢癌（Epithelial ovarian cancers, EOCs）第二常见的亚型，卵巢透明细胞癌（ovarian clear cell carcinoma, OCCC）与较高的癌相关血栓形成（cancer-associated thrombosis）发生率相关。既往研究显示，卵巢透明细胞癌患者中静脉血栓栓塞症（venous thromboembolism, VTE）的患病率范围为6%~42%。本研究旨在明确卵巢透明细胞癌患者中静脉血栓栓塞症的患病率及其影响因素。研究检索了截至2022年12月12日的PubMed、Scopus、Embase及Cochrane Library数据库。纳入报道卵巢透明细胞癌女性患者静脉血栓栓塞事件的相关研究。由两名评价员独立提取患者的人口统计学资料、临床及辅助检查特征。在2254条记录中，最终有43项研究纳入最终综述。符合标准的研究共纳入2965名卵巢透明细胞癌患者，其中573例发生静脉血栓栓塞症。卵巢透明细胞癌患者静脉血栓栓塞症的合并患病率为21.32%（95%CI=17.38~25.87）。多数静脉血栓栓塞事件见于日本女性（26.15%），其次为美国女性（24.41%）、英国女性（21.57%）及中国女性（13.61%）。与疾病早期患者（16.54%）相比，晚期患者的静脉血栓栓塞症发生率更高（37.79%）。综上，卵巢透明细胞癌与较高的癌相关血栓形成发生率相关。卵巢透明细胞癌患者的静脉血栓栓塞事件在晚期患者及日本女性中更为常见。