The Brain Tumor Segmentation in Pediatric Magnetic Resonance Imaging (BraTS-PEDs)

Pediatric central nervous system (CNS) tumors are the leading cause of cancer-related mortality in children. Pediatric high-grade gliomas, particularly diffuse midline gliomas (DMGs), have a dismal prognosis, with five-year survival rates below 20%. The BraTS-PEDs dataset provides a comprehensive, multi-institutional, international resource focused on this disease. It includes 457 pediatric patients with high-grade gliomas, primarily DMGs, aggregated from major pediatric neuro-oncology consortia and institutions, including the Children’s Brain Tumor Network (CBTN), DMG/DIPG Registry, and multiple academic centers. The dataset contains multiparametric structural MRI, expert tumor segmentations, imaging acquisition parameters, demographic variables, and clinical outcomes such as overall and progression-free survival. By integrating standardized imaging, annotations, and clinical data, BraTS-PEDs enables reproducible research and accelerates translation of imaging science into clinical impact.