Data from: Activation recovery interval imaging of premature ventricular contraction

Dispersion of ventricular repolarization due to abnormal activation contributes to the susceptibility to cardiac arrhythmias. However, the global pattern of repolarization is difficult to assess clinically. Activation recovery interval (ARI) has been used to understand the properties of ventricular repolarization. In this study, we developed an ARI imaging technique to noninvasively reconstruct three-dimensional (3D) ARI maps in 10 premature ventricular contraction (PVC) patients and evaluated the results with the endocardial ARI maps recorded by a clinical navigation system (CARTO). From the analysis results of a total of 100 PVC beats in 10 patients, the average correlation coefficient is 0.86±0.05 and the average relative error is 0.06±0.03. The average localization error is 4.5±2.3 mm between the longest ARI sites in 3D ARI maps and those in CARTO endocardial ARI maps. The present results suggest that ARI imaging could serve as an alternative of evaluating global pattern of ventricular repolarization noninvasively and could assist in the future investigation of the relationship between global repolarization dispersion and the susceptibility to cardiac arrhythmias.

异常激活引发的心室复极离散度，会增加心律失常的易感性。然而，临床中尚难以对复极的整体模式进行有效评估。激动恢复间期（Activation recovery interval, ARI）已被用于探究心室复极的相关特性。本研究开发了一种ARI成像技术，可对10例室性早搏（premature ventricular contraction, PVC）患者的三维（3D）ARI图谱实现无创重建，并采用临床导航系统（CARTO）记录的心内膜ARI图谱对重建结果进行验证。针对10例患者共100个PVC心搏的分析结果显示，平均相关系数为0.86±0.05，平均相对误差为0.06±0.03；三维ARI图谱与CARTO心内膜ARI图谱中最长ARI位点的平均定位误差为4.5±2.3 mm。本研究结果表明，ARI成像可作为无创评估心室复极整体模式的有效替代手段，亦可为后续探究整体复极离散度与心律失常易感性之间的关联提供辅助支撑。