Astrocyte-neuron contributions to Huntington's disease dissected with ZFPs
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP348116
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We performed cell-type specific RNAseq in astrocytes and neurons in the presence or absence of ZFP transcriptional repressors in the striatum of R6/2 mouse model of HD. Overall design: Mutant huntingtin was reduced in a cell-specific manner either in astrocytes or neurons using zinc-finger protein (ZFP) transcriptional repressors. Cell-type specific RNA-seq using RiboTag approach was carried out in astrocytes and neurons in combination with mHTT reduction with ZFPs.
创建时间：
2023-02-25
