Effects of stilbenoids 1–3 on inhibition of HaCaT PGE-2 production and COX-2 enzyme activity.

Results are expressed as IC50 (mean ± sd) determined for inhibition of PGE-2 release from UVB (60 mJ/cm2) irradiated HaCaT and inhibition of human recombinant COX-2 activity. IC50 concentration causing half-maximal inhibition of HaCaT PGE-2 production and concentration causing a half-maximal inhibition of COX-2 control specific activity. Gigantol demonstrated strong inhibition of PGE-2 production but did not display concentration dependent effect at the tested concentrations, thus IC50 could not be calculated. Indomethacin was used as a positive reference.