Human phosphodiesterase 9 in complex with inhibitors
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Human phosphodiesterase 9 in complex with inhibitors Descriptor: 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... Authors: Liu, S. Deposit date: 2012-03-20 Release date: 2013-02-27 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J.Med.Chem., 55, 2012
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2012-03-20
