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METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM2457

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Protein Data Bank Japan2024-11-13 更新2026-03-28 收录
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METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM2457 Descriptor: DIMETHYL SULFOXIDE, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, ... Authors: Pilka, E.S, Blackaby, W, Hardick, D, Harper, C, Hewstone, D, Ridgill, M, Rotty, B, Rausch, O. Deposit date: 2021-03-30 Release date: 2021-04-14 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature, 593, 2021
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2021-03-30
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