The rs10830963 SNP of the MTNR1B gene in the Czech cohort

Disruptions in biorhythms contribute to the development of type 2 diabetes mellitus. The <i>MTNR1B</i> gene encodes a receptor for melatonin, a hormone regulating biorhythms, and genetic studies suggest that variability in the <i>MTNR1B</i> gene is related to the development of T2DM, with the single nucleotide polymorphism rs10830963 showing the strongest association. Our aim was to compare the distribution of the genetic variant rs10830963 between persons differing in glucose tolerance (N=1206).

生物节律紊乱可促进2型糖尿病的发生发展。*MTNR1B*基因编码褪黑素（melatonin）受体，褪黑素是一种调控生物节律的激素；遗传学研究表明，*MTNR1B*基因的序列变异与2型糖尿病（type 2 diabetes mellitus，下文简称T2DM）的发生发展存在关联，其中单核苷酸多态性（single nucleotide polymorphism，SNP）位点rs10830963的关联效应最为显著。本研究旨在对比不同糖耐量水平人群中遗传变异位点rs10830963的分布差异，共纳入1206名受试者（N=1206）。