Supplementary Material for: Successful repeated use of a pathogen adsorbing biomimetic device for the adjunct treatment of a SARS-CoV-2 reinfection and subsequent infections with different multi-resistant bacteria

Introduction: The Seraph® 100 Microbind® Affinity filter is a biomimetic adsorbent device that can remove pthogens from the blood. Case presentation: Here we report the successful use of the Seraph® 100 to treat both, a SARS-Cov-2 reinfection leading to severe COVID-19 pneumonia as well as subsequent secondary lung infections with acinetobacter baumannii, serratia marcescens and pseudomonas aeruginosa multi-drug resistant bacteria. To our knowledge this 46-year-old black male is the first patient in which four treatments with this pathogen adsorber, one for a viral and three for different bacterial infections, has been successfully used. Conclusion: The Seraph® 100 in can be easily and successfully used in conjunction with standard (anti-infective) treatment.

引言：Seraph® 100 Microbind® 亲和过滤器（Seraph® 100 Microbind® Affinity filter）是一种仿生吸附装置，可从血液中清除病原体。
病例报告：本文报道了Seraph® 100的成功临床应用案例，共两例：其一为引发重症新型冠状病毒肺炎的严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）再感染，其二为随后并发的鲍曼不动杆菌（Acinetobacter baumannii）、黏质沙雷菌（Serratia marcescens）与铜绿假单胞菌（Pseudomonas aeruginosa）多重耐药菌肺部感染。据我们所知，该46岁黑人男性是首位接受该病原体吸附装置四次治疗的患者：一次用于病毒感染，三次针对不同细菌感染，且所有治疗均获成功。
结论：Seraph® 100可与标准（抗感染）治疗方案联合应用，操作简便且疗效确切。