BindingDB Entry 2751: 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof

Small molecule binding data for protein ABL Mutant (T315I), B-RAF V600E, Bcr-Abl, Discoidin domain-containing receptor 2, Ephrin receptor, Epidermal growth factor receptor, Epidermal growth factor receptor (T790M), Epidermal growth factor receptor(L858R, T790M), Epithelial discoidin domain-containing receptor 1, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Hepatocyte growth factor receptor, High affinity nerve growth factor receptor, Inhibitor of NF-kappa-B kinase alpha/beta, LIM domain kinase 1, MAP kinase p38, Platelet-derived growth factor receptor, Protein-tyrosine kinase 2-beta, Proto-oncogene tyrosine-protein kinase Src (T341M), Proto-oncogene tyrosine-protein kinase Src (aa 1-530), RAF proto-oncogene serine/threonine-protein kinase, Receptor tyrosine-protein kinase erbB-2, SRC, Serine/threonine-protein kinase B-raf, TAK1/TAB1, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase ABL2, Tyrosine-protein kinase BMX, Tyrosine-protein kinase BRK, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Blk, Tyrosine-protein kinase CSK, Tyrosine-protein kinase FRK, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase HCK, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase Lyn, Tyrosine-protein kinase Mer, Tyrosine-protein kinase Yes, Tyrosine-protein kinase receptor UFO, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), and calcineurin A1, putative, Uniprot A0A024QZA8, A0A024R759, A0A024R8E2, A0A024R906, A0A024RCL1, A0A0S2Z3Y8, B2R6Q4, B9W6M3, K7QD41, L7RRS6, L7RSL3, O14920, O15111, O43318, O60674, P00519, P00533, P04049, P04626, P04629, P06239, P06241, P07947, P07948, P08581, P08631, P11362, P15056, P16234, P17948, P21802, P29317, P29323, P30530, P35916, P35968, P41240, P42684, P42685, P51451, P51813, P53667, P54760, Q02763, Q06187, Q08345, Q12866, Q13882, Q15759, Q16832, Q541P7, Q9QVP9, and X5DNK3

本数据集收录针对以下靶点的小分子结合数据：ABL突变体（T315I）（ABL Mutant (T315I)）、B-RAF V600E、Bcr-Abl、盘状结构域受体2（Discoidin domain-containing receptor 2）、Ephrin受体（Ephrin receptor）、表皮生长因子受体（Epidermal growth factor receptor）、表皮生长因子受体（T790M）、表皮生长因子受体(L858R, T790M)、上皮盘状结构域受体1（Epithelial discoidin domain-containing receptor 1）、成纤维细胞生长因子受体1（Fibroblast growth factor receptor 1）、成纤维细胞生长因子受体2（Fibroblast growth factor receptor 2）、黏着斑激酶1/血管内皮生长因子受体3（Focal adhesion kinase 1/vascular endothelial growth factor receptor 3）、肝细胞生长因子受体（Hepatocyte growth factor receptor）、高亲和力神经生长因子受体（High affinity nerve growth factor receptor）、NF-κB激酶α/β抑制剂（Inhibitor of NF-kappa-B kinase alpha/beta）、LIM结构域激酶1（LIM domain kinase 1）、MAP激酶p38（MAP kinase p38）、血小板衍生生长因子受体（Platelet-derived growth factor receptor）、蛋白酪氨酸激酶2-β（Protein-tyrosine kinase 2-beta）、原癌基因酪氨酸蛋白激酶Src（T341M）（Proto-oncogene tyrosine-protein kinase Src (T341M)）、原癌基因酪氨酸蛋白激酶Src（aa 1-530）（Proto-oncogene tyrosine-protein kinase Src (aa 1-530)）、RAF原癌基因丝氨酸/苏氨酸蛋白激酶（RAF proto-oncogene serine/threonine-protein kinase）、受体酪氨酸蛋白激酶erbB-2（Receptor tyrosine-protein kinase erbB-2）、SRC、丝氨酸/苏氨酸蛋白激酶B-raf（Serine/threonine-protein kinase B-raf）、TAK1/TAB1、酪氨酸蛋白激酶ABL1（Tyrosine-protein kinase ABL1）、酪氨酸蛋白激酶ABL2（Tyrosine-protein kinase ABL2）、酪氨酸蛋白激酶BMX（Tyrosine-protein kinase BMX）、酪氨酸蛋白激酶BRK（Tyrosine-protein kinase BRK）、酪氨酸蛋白激酶BTK（Tyrosine-protein kinase BTK）、酪氨酸蛋白激酶Blk（Tyrosine-protein kinase Blk）、酪氨酸蛋白激酶CSK（Tyrosine-protein kinase CSK）、酪氨酸蛋白激酶FRK（Tyrosine-protein kinase FRK）、酪氨酸蛋白激酶Fyn（Tyrosine-protein kinase Fyn）、酪氨酸蛋白激酶HCK（Tyrosine-protein kinase HCK）、酪氨酸蛋白激酶JAK2（Tyrosine-protein kinase JAK2）、酪氨酸蛋白激酶Lyn（Tyrosine-protein kinase Lyn）、酪氨酸蛋白激酶Mer（Tyrosine-protein kinase Mer）、酪氨酸蛋白激酶Yes（Tyrosine-protein kinase Yes）、酪氨酸蛋白激酶受体UFO（Tyrosine-protein kinase receptor UFO）、血管内皮生长因子受体1（Vascular endothelial growth factor receptor 1）、血管内皮生长因子受体2（Vascular endothelial growth factor receptor 2）、血管内皮生长因子受体2与酪氨酸蛋白激酶TIE-2（KDR和TIE2）（Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)）、假定钙调神经磷酸酶A1（calcineurin A1, putative）；同时涵盖以下通用蛋白知识库（UniProt）条目：A0A024QZA8、A0A024R759、A0A024R8E2、A0A024R906、A0A024RCL1、A0A0S2Z3Y8、B2R6Q4、B9W6M3、K7QD41、L7RRS6、L7RSL3、O14920、O15111、O43318、O60674、P00519、P00533、P04049、P04626、P04629、P06239、P06241、P07947、P07948、P08581、P08631、P11362、P15056、P16234、P17948、P21802、P29317、P29323、P30530、P35916、P35968、P41240、P42684、P42685、P51451、P51813、P53667、P54760、Q02763、Q06187、Q08345、Q12866、Q13882、Q15759、Q16832、Q541P7、Q9QVP9以及X5DNK3