Supporting Dataset for thesis - "New World vs Old World: Refining the screening, diagnosis, and prediction of oral cancer"

This data contains supporting resources for the thesis titled "New World vs Old World: Refining the screening, diagnosis, and prediction of oral cancer". The thesis was based on eight studies which were generated from the five datasets included in the files. The first dataset (RRBS Dataset) was generated following reduced representation bisulfite sequencing of salivary DNA samples obtained from patients with oral cancer and oral potentially malignant dataset. The differentially methylated CpG sites (CPG Dataset) and differentially methylated regions (DMR Datasets) are provided in different spreadsheets. The second dataset (Bayesian mapping Dataset) comprises counts of oral cancer incidence and mortality in Hong Kong from January 2013 to December 2019. The count was obtained from the CDARS data ecosystem in Hong Kong. The third dataset (Oral cancer prognosis dataset) was obtained with ethical approval from the Hospital Authority Clinical Management System (HA-CMS). It contains information about oral cavity cancer patients in Hong Kong treated at the Queen Mary Hospital from 2000 to 2019. The fourth dataset (Oral cancer screening dataset) was obtained from a community-based oral cancer screening program in Hong Kong conducted between November 2020 to June 2022. Information about demographics, lifestyle, family history, comorbidity, and expired carbon monoxide was collected at these events and presented in the dataset. The fifth dataset (Oral potentially malignant disorders dataset) was also obtained from the HA-CMS for patients with oral leukoplakia and oral lichenoid mucositis to predict malignant transformation. For all datasets, further information explaining individual variables are within the spreadsheets.

本数据集为论文《新世界与旧世界：优化口腔癌的筛查、诊断与预测》提供配套支撑资源。该论文基于8项研究，其数据来源于本文件所包含的5个数据集。首个数据集（RRBS数据集，RRBS Dataset）是对口腔癌及口腔潜在恶性病变患者的唾液DNA样本开展简化代表性亚硫酸氢盐测序后得到的。不同电子表格中分别提供了差异甲基化CpG位点（CPG Dataset）与差异甲基化区域（DMR数据集）的相关数据。第二个数据集（贝叶斯映射数据集，Bayesian mapping Dataset）涵盖2013年1月至2019年12月香港地区口腔癌的发病与死亡计数数据，该数据来源于香港CDARS数据生态系统。第三个数据集（口腔癌预后数据集，Oral cancer prognosis dataset）经香港医院管理局临床管理系统（HA-CMS）伦理审批后获取，包含2000年至2019年于香港玛丽医院接受治疗的口腔癌患者相关信息。第四个数据集（口腔癌筛查数据集，Oral cancer screening dataset）来源于2020年11月至2022年6月香港开展的社区口腔癌筛查项目，该数据集收录了筛查现场收集的人口统计学特征、生活习惯、家族病史、合并症以及呼出气一氧化碳水平等相关信息。第五个数据集（口腔潜在恶性病变数据集，Oral potentially malignant disorders dataset）同样来源于HA-CMS，针对口腔白斑与口腔苔藓样黏膜炎患者，用于预测其恶性转化风险。所有数据集的各变量详细说明均包含在对应电子表格中。