Amber photobiomodulation versus tranexamic acid for the treatment of melasma: Randomized controlled Double-blind

This is the data sheet colected from a pilot study.
21 women presenting melasma were included. Ten of them received effective PBM and placebo cosmetic product while 11 received sham PBM and liposomal ATX. The protocol included once a week PBM sessions (590nm and 20 J/cm2) and cosmetic product twice a day for 12 weeks. The main outcome measure was MASI score. Secondary outcomes include corneomelametry, photos analysed by Global Skin Diagnosis, the Brazilian Portuguese version of the Melasma Quality of Life Questionnaire (MELASQoL) and adverse events record.

本数据集来源于一项先导性研究。本研究共纳入21名黄褐斑（melasma）女性患者，其中10名接受有效光生物调节疗法（Photobiomodulation, PBM）联合安慰剂类化妆品治疗，其余11名接受假光生物调节疗法联合脂质体包裹ATX制剂治疗。研究方案为：每周开展1次光生物调节治疗（波长590nm，能量密度20 J/cm²），同时每日外用化妆品2次，持续干预12周。本研究的主要结局指标为黄褐斑面积与严重程度指数（Melasma Area and Severity Index, MASI）评分；次要结局指标包括角质层黑素测量法（corneomelametry）、全球皮肤诊断系统（Global Skin Diagnosis）分析的皮肤图像、巴西葡萄牙语版黄褐斑患者生活质量问卷（Melasma Quality of Life Questionnaire, MELASQoL）以及不良事件记录。