Association of MUC5AC VNTR allele sizes with lung disease severity (“Severe” versus “Mild”)†.

For each test, a specific size is denoted the “Designated” allele (allele D), and is compared to all other alleles (non-D). The number of patients (n = 468; Severe = 194; Mild = 274) with each genotype (D, D; D, non-D; and non-D, non-D) is given for each test.†Analyzed only for allele sizes that were present in ≥ 4% of the population.‡6.35 kb (and 6.30 kb) allele tends to associate with “mild” disease, but is not significant after Bonferroni correction.*6.4 kb allele associates with “severe” lung disease; Bonferroni corrected p value for the tests indicated in this Table (8 tests total), p = 1.1×10−4; corrected p value for the tests in this Table, plus the original tests for association with lung disease severity shown in Figure 2 (12 tests total), p = 1.7×10−4; corrected p value for all tests directly above, plus the additional tests utilizing the cut-point analysis in Figure S3 (15 tests total), p = 2.1×10−4; corrected p value for all tests directly above, plus the MUC1 and MUC2 VNTR allele size tests for association (data not shown; 29 tests total), p = 4.1×10−4; corrected p value for all tests directly above, plus SNPs in Table S3 (44 tests total), p = 6.2×10−4.