BIOGRID CURATED DATA FOR PHO89 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for PHO89 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Plasma membrane Na+/Pi cotransporter; active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification

PHO89 (Saccharomyces cerevisiae S288c) 的蛋白质-蛋白质、遗传和化学相互作用数据集，由 BioGRID (https://thebiogrid.org) 精心编纂；定义：质膜钠/磷共转运蛋白；在早期生长阶段活性；与光滑念珠菌的磷酸盐转运蛋白相似；转录受无机磷酸盐浓度和 Pho4p 的调控；与人类转运蛋白基因 hPit1 和 hPit2 相关的突变与由高磷酸盐血症引起的血管组织钙化以及家族性特发性基底神经节钙化相关。