KCNE3

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]

电压门控钾离子通道（Kv通道）在功能和结构上均代表着最复杂的一类电压门控离子通道。它们的功能多样性包括调节神经递质的释放、心率、胰岛素分泌、神经元兴奋性、上皮细胞电解质运输、平滑肌收缩以及细胞体积。该基因编码钾通道电压门控、isk相关亚家族的成员。该成员是一种I型膜蛋白，同时也是β亚单位，它与钾通道α亚单位组装，以调节门控动力学并增强多聚复合物的稳定性。该基因在肾脏中表达显著。该基因中的错义突变与低钾性周期性麻痹相关。[由RefSeq提供，2008年7月]