Williams_et_al_extended_data

These extended data documents relate to the manuscript
titled " Genome-wide association study of susceptibility to hospitalised
respiratory infections", which has been submitted to Wellcome Open Research,
and include the following files:

·
Supplementary materials and methods

·
Supplementary figures

·
Table S1: ICD-10 codes used to define the
hospitalised respiratory infection phenotype.

·
Table S2: ICD-9 codes used to define the
hospitalised respiratory infection phenotype in CHS and Partners Biobank.

·
Table S3: Summary statistics for the 56 sentinel
variants from the discovery GWAS in UK Biobank.

·
Table S4: Availability of the 40 sentinel
variants in the 11 follow-up cohorts.

·
Table S5: Results of the inverse
variance-weighted fixed effects meta-analysis.

·
Table S6: Fine-mapping of the 56 association
signals.

·
Table S7: Functional annotation of variants in
the 95% credible sets.

·
Table S8: Association between variants in the
95% credible sets and gene expression across 48 tissues from GTEx (v7).

·
Table S9: Association between variants in the
95% credible sets and gene expression across three major human immune cell
types from BLUEPRINT.

·
Table S10: Association between variants in the
95% credible sets and gene expression (cis-eQTLs) from eQTLGen.

·
Table S11: Colocalisation results from PICCOLO.

·
Table S12: Look-up of the sentinel variants in
the 56 association signals in existing GWAS.

·
Table S13: Look-up of the sentinel variants in
the 56 association signals in existing GWAS.

·
Table S14: Look-up of the sentinel variants in
the 56 association signals in the COVID-19 Host Genetics Initiative
meta-analysis results.

Main materials and methods can be found in the main manuscript
text.