Whole Transcriptome Sequencing of Metastatic Hepatocellular Carcinoma in an Orthotopic SCID Mice Model

Globally, Hepatocellular carcinoma (HCC) is a difficult to treat solid tumors and the third cause of mortality from cancer. It is heterogeneous with complex genetic alteration. The present study depicts the unique whole transcriptomic molecular signatures of metastatic Hepatocellular carcinoma in an orthotopic SCID mice model, and in normal liver tissues carried out on a HiSeq Illumina platform. The RNAseq NGS liver transcriptomes would important aspects for understanding the molecular mechanisms, and strategies targeting the genes for metastatic HCC therapeutics.