Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study

Abstract The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region.

摘要 本研究旨在描述口腔颌面区域腺泡细胞癌（acinic cell carcinoma, AciCC）的患病率、临床病理及预后特征。本研究回顾性收集了来自3个不同国家的11个病理中心的腺泡细胞癌病例，通过查阅病历资料提取人口统计学、临床、病理及随访相关信息，最终共纳入75例病例。女性患者占比65.33%，平均年龄45.51岁，为主要发病人群。病变多表现为腮腺（70.68%）部位无症状（64.28%）的结节状肿物（95.66%）。最常见的病理表现为两种组织学模式并存（48.93%），肿瘤以常规组织学分级为主（86.11%）。多数病例（59.19%）接受了手术治疗。在具备完整随访数据的病例中，局部复发率为20%，区域淋巴结转移率为30.43%，远处转移率为12.50%。统计学分析显示，存在实体组织学模式（p=0.01）、高级别转化（p=0.008）、复发（p=0.007）及区域转移（p=0.03）的病例与不良预后显著相关。综上，高级别组织学转化、淋巴结转移及复发是口腔颌面区域腺泡细胞癌的预后危险因素。