Data for total or non-vertebral fracture in each meta-analysis.

Data are for total fracture unless otherwise indicated. Individual trial data for fracture were not reported in DIPART 2010 [20], or Bischoff-Ferrari 2012 [22]. No data on total or non-vertebral fracture were reported in any meta-analysis for Bischoff 2003 [33], and Bischoff-Ferrari 2010 [48].
Study excluded- study met meta-analysis exclusion criteria. Study not included- study did not meet exclusion criteria but not included in meta-analysis. Data not included- data not included in meta-analysis but available from other meta-analyses or primary publication.
Abbreviations: Vit D- vitamin D, RR- relative risk, CI confidence interval. NS- not stated. Vit D- vitamin D. CaD- co-administered calcium and vitamin D.
Bold text- indicates differences in relative risks for individual studies between meta-analyses.
afactorial/multi-arm studies permitting multiple comparisons between randomised groups.
Reasons for differences in reported data between meta-analyses: bnon-vertebral fracture,
cdata after 36 month from Chapuy 1994;
dper-protocol analysis (all randomised participants not included);
edata after 18 month from Chapuy 1992;
fhip fractures plus all non-vertebral fractures;
goriginal paper reports different numbers for placebo group, correct numbers confirmed by original authors in Avenell 2009;
hhip/wrist/forearm fracture used for non-vertebral fractures;
iunknown how calculated;
jexcluded participants receiving intramuscular vitamin D;
kincludes participants receiving intramuscular vitamin D;
losteoporotic fracture;
mfracture numbers calculated indirectly from Table 3 in meta-analysis;
nlow trauma fractures;
olow trauma non-vertebral fractures;
pparticipants with vertebral fracture subtracted from participants with low trauma fractures;
qadjustments to the number of participants with outcomes and denominators were made using an intraclass correlation coefficient of 0.026 to account for cluster randomisation;
rsubgroup of participants only;
ship fractures used for non-vertebral fractures;
tparticipants with vertebral fractures subtracted from participants with all fractures;
urelative risk only reported for two subgroups,
vtotal numbers of fractures (not numbers of participants with fracture).
Data for total or non-vertebral fracture in each meta-analysis.