Binding energy changes between DNA and the p53 core domain due to temperature alterations.
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https://figshare.com/articles/dataset/_Binding_energy_changes_between_DNA_and_the_p53_core_domain_due_to_temperature_alterations_/383540
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Note: BEWT300K = −12 kcal/mol.All binding energies are relative to that of the WT at 300 K. Our calculations predict that the WT p53 maintains its DNA binding at all temperatures. On the other hand, while the Glu-248 mutant (R248Q) does not lose its DNA binding activity at 300 K, binding is highly unfavorable at 310 K.
创建时间：
2015-12-02
