Institut Pasteur BAG - Structural biology of infectious agents

The Institut Pasteur’s BAG gathers the projects of the research units and platforms of the Institut Pasteur in Paris which are active in the structural biology field: Structural Microbiology (P.M. Alzari), Structural Dynamics of Macromolecules (M. Delarue), Structural Virology (F. Rey) and the Platform of Crystallography (A. Haouz). The non-exhaustive list of ongoing projects includes: - actinobacterial SepF, FtsZ and other cell division proteins; - central metabolic enzymes from actinobacteria; - DNA gyrase from Mycobacterium tuberculosis or model organisms; - Plasmodium proteases as drug targets; - bacterial models of pentameric ligand-gated ion channel family (pLGIC) receptors; - eukaryotic and archeal DNA polymerases and replisome proteins; - viral envelope proteins from pathogenic viruses, and their complexes with neutralizing antibodies; - enzymes and structural proteins from other human pathogens, supported by evolving national and international collaborations.

巴斯德研究所（Institut Pasteur）的BAG库收录了巴黎巴斯德研究所各研究单元与平台的科研项目，相关团队均活跃于结构生物学领域，具体包括：结构微生物学研究组（由P.M. Alzari负责）、大分子结构动力学研究组（由M. Delarue负责）、结构病毒学研究组（由F. Rey负责）以及晶体学平台（由A. Haouz负责）。该库涵盖的在研项目非详尽清单如下：
- 放线菌的SepF、FtsZ及其他细胞分裂蛋白；
- 放线菌的核心代谢酶类；
- 结核分枝杆菌或模式生物中的DNA旋转酶；
- 作为药物靶点的疟原虫蛋白酶；
- 五聚体配体门控离子通道家族（pentameric ligand-gated ion channel，pLGIC）受体的细菌模型；
- 真核与古菌DNA聚合酶及复制体蛋白；
- 致病病毒的包膜蛋白及其与中和抗体的复合物；
- 其他人类病原体相关的酶类与结构蛋白，相关研究得到了持续发展的国内外合作支持。