Supplementary Material for: A Characterization Study of the Patients Visiting Hospital due to Laryngopharyngeal Reflux Suspicion: A Prospective Case-Control Study

<b><i>Background:</i></b> This study aimed to explore the characteristics of laryngopharyngeal reflux (LPR) and the association between LPR and allergic rhinitis (AR). <b><i>Methods:</i></b> In this prospective case-control study, a total of 102 patients with suspected LPR who visited the Department of Otolaryngology Head and Neck Surgery, Heping Hospital Affiliated to Changzhi Medical College, between June 2019 and June 2021 were consecutively included. They were divided into the LPR-positive group and the LPR-negative group according to 24-h Dx-pH monitoring. The influencing factors of LPR, including the scores for AR (SFAR) and AR prevalence, were compared between the two groups. <b><i>Results:</i></b> The total SFAR and scores in items 1, 3, 4, and 5 of the LPR-positive group were significantly higher than those of the LPR-negative group (<i>p</i> &lt; 0.05). The prevalence of AR in the LPR-positive group was 60%, which was significantly higher than that in the LPR-negative group (36.54%) (<i>p</i> &lt; 0.05). After excluding confounding factors, AR was positively correlated with the incidence of LPR, and the incidence of LPR with AR was 2.372 times that of non-AR. Receiver operating characteristic curve results show that AR has the highest predictive value for LPR, and the area of AR under the curve is was 0.617. <b><i>Conclusions:</i></b> The SFAR and incidence of AR are high in patients with positive LPR, and AR may be a risk factor for LPR. The results of this study may deepen our understanding of the occurrence of LPR.

**背景**：本研究旨在探讨咽喉反流（LPR）的临床特征，以及咽喉反流与变应性鼻炎（AR）之间的关联。
**方法**：本研究为前瞻性病例对照研究，连续纳入2019年6月至2021年6月期间于长治医学院附属和平医院耳鼻咽喉头颈外科就诊的102例疑似咽喉反流患者。所有受试者均接受24小时DX-pH监测，并据此分为咽喉反流阳性组与咽喉反流阴性组。比较两组患者咽喉反流的相关影响因素，包括变应性鼻炎评分（SFAR）以及变应性鼻炎患病率。
**结果**：咽喉反流阳性组的变应性鼻炎总评分及第1、3、4、5项分项评分均显著高于咽喉反流阴性组（p < 0.05）。咽喉反流阳性组的变应性鼻炎患病率为60%，显著高于咽喉反流阴性组的36.54%（p < 0.05）。排除混杂因素后，变应性鼻炎与咽喉反流的发生呈正相关，合并变应性鼻炎的咽喉反流发生率是非变应性鼻炎人群的2.372倍。受试者工作特征曲线（ROC）结果显示，变应性鼻炎对咽喉反流具有最高的预测价值，其曲线下面积为0.617。
**结论**：咽喉反流阳性患者的变应性鼻炎评分及变应性鼻炎患病率均较高，变应性鼻炎可能是咽喉反流的危险因素。本研究结果可加深我们对咽喉反流发生过程的理解。